This is a gorgeous, lush region of New York that boasts numerous narrow lakes plunked down—like a hand—between Lake Ontario and the Pennsylvania border. As you explore this beautiful 9,000-square mile area you’ll come across stunning backdrops featuring eye-popping lakes, waterfalls and gorges as well as sophisticated cultural offerings. The deep glacial lakes create the perfect environment to grow grapes and today there are more than 100 wineries (Riesling is the region’s specialty) which attract a steady stream of tourists. Experience multiple waterfalls and a stunning gorge as you hike Watkins Glen State Park. Dairy farms dot the area, which offers a culinary bounty. (Don’t miss the super fun cheese trail!) Amtrak stops in Syracuse—a vibrant and historic college city with multiple museums and a walkable downtown. It also stops in Rochester—known for flowers, festivals and being the birthplace of camera titan Kodak. It also has the nation’s only museum dedicated to play.